Non-clinical Test (in-vivo)
NEXJENNER SERVICE
This is a test to evaluate the efficacy of new drugs,
functional foods, or cosmetics using experimental animals.
Non-clinical in-vivo testing proves the efficacy of a new drug or functional food in a logical and reasonable manner through animal testing in the non-clinical stage before entering clinical trials
At Nexjenner Co., Ltd., researchers with academic expertise and skilled technology place the safety and life of animals as the top priority and provide reliable test results based on ethical animal testing.
Test Evaluation Items
Test items
Brain Disease (dementia, etc.)
Blood-brain barrier (BBB) permeability evaluation test/Maze test
Psoriasis
Imiquimod-Induced Psoriasis Model
Allergy
Passive cutaneous anaphylaxis model/Systemic anaphylaxis model/Ovalbumin-induced asthma
Atopy
OVA sensitization atopy test/Skin irritation atopy test
Immunity Enhancement
Evaluation of fatigue recovery efficacy in fatigue accumulation model
Measurement of steatorrhea improvement effect/Evaluation of hangover relief efficacy
Degenerative Arthritis
MIA-induced OA model, Anti-inflammatory evaluation in macrophages(RAW264.7 cells)
and monocytes(THP-1) in ACLT/MM-induced OA model
Sepsis
Anti-inflammatory evaluation in macrophages(RAW264.7 cells) and monocytes(THP-1)
in LPS-induced sepsis model
Gastritis/
Stomach Ulcer
Drug-induced model (EtOH-HCl, Indomethacin)
Inflammatory Enteritis
DSS-induced IBD (Inflammatory bowel disease) model
Pulmonary Fibrosis
Bleomycin induced Pulmonary Fibrosis Model
Anti-Cancer
Xenograft Model/Metastasis Model
Diabetes
Type I diabetes model evaluation (STZ-induced blood sugar lowering effect),
Type II diabetes model evaluation (anti-diabetic effect using db/db mouse)
Obesity
DIO ⅠModel/DIO Ⅱ Model
Acute Liver Injury
AAPH-Induced liver Injury Model/LPS/Galactosamine Model
Fatty Liver
DIO-NAFLD Model
Acute Kidney Injury
UUO model/Cisplatin-Induced Renal Injury Model
Musculoskeletal
/Nervous System
Electromyography (ECG)/motor function evaluation: Grip strength/Rota rod/Thread mill/Maze test
Hair Loss
Hair growth promotion evaluation: C57BL/6 mouse
Immunoassay
(Vaccine) Immunogenicity Analysis: ELISA/Flow cytometry
(Vaccine) antibody titer analysis: ELISA/ isotype-specific ELISA
Cytokine analysis and immune cell profile analysis
Sleep Disorder
Measurement of blood cortisol/serotonin/dopamine/testosterone
and growth factor contents Y-maze test
Dementia
Y-maze test
Main Facilities and Equipment
Animal Breeding Room
Laboratory
Organizational Evaluation Room
New Drug Evaluation Room: Genetic analysis and protein analysis system equipment such as real-time
PCR and Western blotting
Drug efficacy Analysis Laboratory : Clean bench for cell culture/CO2 incubator/automatic cell counter (countess)
Cell culture Room: breeding equipment (IVC rack, etc.)/anesthesia equipment/and behavioral observation system
equipment for hygienic management of laboratory animals
Animal laboratory: confocal microscope/fluorescence microscope, etc.
Microscope Room: analysis systems such as ELISA reader/Chemi-Doc/FACS/etc.
Tissue/Biochemical Evaluation Lab: Animal tissue slide production/tissue imaging equipment for staining/ and
blood biochemical analysis equipment
Bio-image analysis Lab: micro-CT/in-vivo imaging system
Behavioral Evaluation
Treadmill
Rotarod
Tail Suspension Test
Y-maze
Water Maze
Grip Strength
Clinicopathological Evaluation
Blood Biochemistry Analyzer
Hematology Analyzer
Histopathological Evaluation
Tissue Processing
Tissue Embedding Center
Tissue Staining