ASO & siRNA

NEXJENNER SERVICE

ASO(Antisense Oligonucleotide)is

a short single-stranded nucleic acid molecule consisting of 15 to 25 base nucleotides that is used to inhibit the expression of a specific mRNA. It binds complementary to a specific site on the mRNA and interferes with translation.

siRNA(Small Interference RNA)is

a short, double-stranded RNA molecule that inhibits mRNA expression through the RNA interference pathway.
It selectively destroys a sequence with complete complementarity by targeting a specific mRNA.

ASO

siRNA

Structure

Single-Stranded

Double-Stranded

Length

12~30 bp

19~25 bp

Molecular Weight

4~10 kDa

~14 kDa

Site of Action

Cytoplasm/Nucleus

Cytoplasm

mRNA Cleavage

RNase H

RISC

Effective Concentration

50~400 nM

5~100 nM

ASO & siRNA Design and Development Support Services

Target Gene Selection

Gene selection of target protein through sequence analysis

Custom Design & Production

Detailed sequencing and specificity assessment for your research goals and needs

Physical and Chemical

Analysis & DDS Optimization

·Proposal and optimization of efficient intracellular delivery methods

·LNP, GalNAc and CPP

BGMP API Production

Small-scale production of non-clinical and clinical API

Toxicity Verification &

Validation

Cell culture, gene expression analysis, etc.

* DDS: Drug Delivery System